After the accident of Fukushima NPP, NNSA requires that Seismic Margin Assessment(SMA) should be implemented on all operational NPPs in China mainland. This paper describes the SMA process and result of 650 MW PWR unit in Qinshan II Nuclear Power Plant. It is shown that the SMA of 650 MW PWR unit satisfies the requirement of NNSA and complies with the EPRI-NP-6041 as well as the seismic safety margin.