In view of the information security problems that Modbus/TCP protocol is facing, this paper discusses 5 kinds of information security services which are lacked in the protocol, and describes the threats on the information safety brought by the lack of the services. To solve the problems, this paper designs a practical measure in Modbus/TCP information security defense for cyber security in Nuclear Advanced Safety Platform Instrumentation and Control(NASPIC), including access control, integrity check, encryption certification and safety alarm.