This paper discusses the effects of different proportions of fresh fuel assemblies number on neutronic data with SCIENCE V2 package. A fixed loading parttern with 64 fresh fuel assemblies is applied in order to reach a equilibrium state by adjustment of enrichment and Gadolinium rod numbers in fresh fuel assemblies. There are five typical proportion of fresh fuel assemblies with the enrichments of 4.45% and 4.95%, respectively. The effects of different proportion on the generic nuclear data, key neutronic parameters and specific accidental neutronic data are provided. The results show a high flexibility of cycle length. The propotion of fresh fuel assemblies of different enrichements has no effect on the limits of general nuclear data, key neutronic parameters and specific accidental neutronic data.