The problem that "large machine and small grid" in Hainan Changjiang Nuclear Power Plant is prominent. The load factor is greatly lower than the average level of nuclear power units in China, due to the long-term low power operation, which has great influence on the safety and economy of the unit. It is important for improving the safety and economy to study the extended nuclear fuel cycle. In this paper, the feasibility of the extended nuclear fuel cycle in Changjiang Nuclear Power Plant is studied, and the main safety parameters of the reactor core are calculated. The results show that the long cycle fuel management strategy can enhance the utilization rate of the unit, while meeting the requirements of the safety of the unit.