In order to study the erosion of liquid lead-bismuth eutectic(LBE) alloy fluid with particles, the fluid erosion on the pipe wall was numerical simulated by the discrete phase model (DPM) of Fluent, based on the theory of fluid mechanics. The results show that the angle of the elbow, the particle size, the particle concentration, the pipe diameter and the velocity of the flow have a significant effect on the erosion wear of the pipe wall. At high flow rates, the erosion is serious, and the erosion on the straight pipe section is much weaker. The maximum erosion rate of the elbow is mainly distributed in the range of 30° to 90°. The erosion of micro particles in the range of 1μm and 9 μm is small, but cannot be ignored. When the particle size is in the range of 10μm to 90μm, the erosion rate is not much different from that of micro particles. When the particle size increases to the range of 100 μm to 900 μm, the erosion of large-diameter particles is severe.