Abstract: On the basis of Rankine-Cycle, this paper introduces the characteristics and innovative advantages of Kalina-Cycle, and briefs the development status in other countries. It mainly analyzes and describes the feasibility of applying Kalina-Cycle in second-loop of nuclear power plants academically. The conclusion indicates that by applying Kalina-Cycle, the thermal efficiency of nuclear power plants can be increased by above 10% and the costs of investment in circulating cool-water system and reheating system can also be decreased considerably. However, the change of medium in second-loop of nuclear power plants will change the heat energy system accordingly, in addition, the change of thermal system will lead to the re-R＆D of the whole thermal system facilities.Whether Kalina-Cycle can be used in the second-loop system of nuclear power plant, there are still many problems to be reviewed.