Abatract: Deep hole drilling of steam generator tube sheet assembly is an important process for SG fabrication. This process is always difficult during manufacturing. The SG Tube sheet of Sanmen AP1000 Units is thicker than that of Nuclear Power Generate II+. The difficulty of Tubesheet Drilling also grows with the larger thickness. This paper describes the disposition of SG Tube sheet drilling deviation for Sanmen Nuclear Power Plant Unit 2. It is expected to provide some useful experience for the future SG manufacturing, avoiding such problem occurs again.