In this paper, a fatigue analysis method suitable for RCC-M class 1 component was presented based on Miner linear cumulative damage theory, rain-flow counting method and RCC-M requirement. it also provided an optimized fatigue analysis method-Group Combination method by considering the actual operation condition. One simulated example was induced to present this optimized method. The result shows that Group Combination method allows to perform the analysis with more reality to the real situation and allows to obtain the result with more accuracy.