A new Monte Carlo criticality search method based on perturbation calculation is Carry out in this paper to overcome the disadvantages of traditional method. By using only one criticality run to get initial keff and differential coefficients of concerned parameter, the polynomial estimator of keff changing function is solved to get the critical value of concerned parameter. The feasibility of this method is tested, and results show that the accuracy and efficiency of perturbation based criticality search method is quite inspiring and overcomes the disadvantages of the traditional method.